The Submillimeter Array was the first observatory capable of imaging and spectroscopy at sub-arcsecond angular resolution at submillimeter wavelengths. The SMA has made many fundamental contributions to astronomy from the study of nearby protoplanetary disks to distant, high-redshift submillimeter galaxies. The SMA has been a pioneer in developing submillimeter instrumentation, particularly wideband receivers and electronics. The ten years since the dedication of the SMA in 2003 have been a decade of discovery in submillimeter astronomy. Celebrating 10 years of research with the SMA and looking forward to the future, this conference focuses on submillimeter-wavelength science at high angular resolution. Topics to be covered include star formation, proplanetary disks, nearby and distant galaxies, magnetic fields in the interstellar medium, high-energy and time-variable phenomena, the galactic center, the solar system, and submillimeter instrumentation.